(R)-N2-Indan-1-yl-quinoline-2,6-diamine → HCID 44218876, compound

Participants

Reaction Conditions

Reaction Steps

1-Methyl-3-(morpholine-4-sulfonyl)-3H-imidazol-1-ium trifluoromethanesulfonate (0.139 g, 0.36 mmol) and (R)—N2-indan-1-yl-quinoline-2,6-diamine (0.10 g, 0.36 mmol) were dissolved in acetonitrile (2 mL) and stirred for 16 h at 80° C. The solvent was removed and the residue subjected to column chromatography (silica gel, heptane, ethyl acetate 4:1/1:1) to yield morpholine-4-sulfonic acid [2-((R)-indan-1-ylamino)-quinolin-6-yl]-amide (0.07 g, 45%) as a yellow solid; MS: m/e=425.7 (M+H+).

Provenance & Evidence