HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → 1-[2-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-quinolin-6-yl]-3-((r)-1-methyl-pyrrolidin-3-yl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | (3R)-3-Amino-1-methylpyrrolidine | HCID 21034111 | — |
| Reactant | Rac-n2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine | HCID 57860959 | — |
| Product | 1-[2-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-quinolin-6-yl]-3-((r)-1-methyl-pyrrolidin-3-yl)-urea | HCID 44218573 | — |
Reaction Steps
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, (3R)-1-methyl-3-pyrrolidinamine (CAS no: 457097-75-5) and rac-N2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine; MS: m/e=446.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183380B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e6327d60270e457ba7984c85670a0be3 |
| Source note | uspto-grants-2012_05 |