N,N-Dimethylglycine → HCID 57860963, compound

Participants

Reaction Steps

N,N-Dimethylglycine (49 mg, 0.48 mmol), N,N-diisopropyl ethyl amine (217 mg, 1.68 mmol) and 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (220 mg, 0.69 mmol) were dissolved in dichloromethane (6 mL) and dimethylformamide (1.5 mL). The reaction mixture was stirred at room temperature for 30 minutes. rac-N2-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine (150 mg, 0.47 mmol) was added and stirred was continued overnight. The reaction mixture was diluted with water and extracted with dichloromethane (3×). The combined organic phases were dried over sodium sulfate and evaporated. The crude product was purified by column chromatography (silica gel, dichloromethane/methanol 100:0→90:10). The title compound (147 mg, 77%) was obtained as a light brown solid; MS: m/e=405.5 (M+H+).

Provenance & Evidence