Triethylamine → HCID 44219345, compound

Participants

Reaction Steps

1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-piperidin-4-yl-urea (0.05 g, 0.12 mmol), triethylamine (0.02 mL, 0.15 mmol) and methylvinylsulfone (0.016 g, 0.15 mmol) were dissolved in tetrahydrofuran (3 mL) and stirred at ambient temperature for 16 h. Ethyl acetate (10 mL) was added to the reaction mixture and everything subsequently washed with water. The organic phase was dried over sodium sulfate, filtered and the filtrate evaporated. The residue was subjected to column chromatography (basic silica gel, ethyl acetate) to yield the title compound (0.026 g, 41%) as an off-white solid; MS: m/e=508.8 (M+H+).

Provenance & Evidence