Cyclopropanecarboxylic acid → Rac-cyclopropanecarboxylic acid [2-(5-fluoro-indan-1-ylamino)-quinolin-6-yl]-amide

HRID 1928834Notes

Reaction equation

HRID 1928834 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH:11][C:12]1[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH2:22])[CH:18]=3)[N:13]=1)[CH2:6][CH2:5]2.[CH:23]1([C:26](O)=[O:27])[CH2:25][CH2:24]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH:11][C:12]1[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:22][C:26]([CH:23]4[CH2:25][CH2:24]4)=[O:27])[CH:18]=3)[N:13]=1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 68638772HCID 68638772, compound

Product 1

HCID 91613877Rac-cyclopropanecarboxylic acid [2-(5-fluoro-indan-1-ylamino)-quinolin-6-yl]-amide

Procedure

The title compound was prepared in accordance with the general method 14 described in example 119 from rac-N2-(5-fluoro-indan-1-yl)-quinoline-2,6-diamine and cyclopropyl carboxylic acid; MS: m/e=362.2 (M+H+).

Sources & evidence

ORD record
ord-967da3a32f994a0193da6c88b863cfe4
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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