2-Chloro-6-nitroquinoline → Rac-n2-(6-fluoro-indan-1-yl)-quinoline-2,6-diamine

HRID 1928836Notes

Reaction equation

HRID 1928836 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-])=O)[CH:8]=2)[N:3]=1.[F:15][C:16]1[CH:24]=[C:23]2[C:19]([CH2:20][CH2:21][CH:22]2[NH2:25])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:24]=[C:23]2[C:19]([CH2:20][CH2:21][CH:22]2[NH:25][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([NH2:12])[CH:8]=3)[N:3]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 109217232-Chloro-6-nitroquinolineHCID 154081276-Fluoro-2,3-dihydro-1H-inden-1-amine

Product 1

HCID 68639984Rac-n2-(6-fluoro-indan-1-yl)-quinoline-2,6-diamine

Procedure

The title compound was prepared in accordance with the general method described in example 2 from 2-chloro-6-nitro-quinoline and rac-6-fluoro-indan-1-ylamine (CAS no: 168902-77-0); MS: m/e=294.3 (M+H+).

Sources & evidence

ORD record
ord-962c08492cd34907ba9850af4453c2cf
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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