Morpholine → HCID 178511933, compound

Participants

Reaction Steps

1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-2-methyl-isothiourea hydroiodide (345 mg, 0.72 mmol) was dissolved in 10 mL ethanol. Morpholine (350 mg, 4 mmol) was added and the reaction mixture was refluxed overnight. The solvent was evaporated and the residue was purified by column chromatography (silica gel, dichloromethane/methanol 40:1). The title compound (144 mg, 51%) was obtained as a light yellow foam; MS: m/e=388.3 (M+H+).

Provenance & Evidence