Cyclopropaneacetic acid → Rac-2-cyclopropyl-n-[2-(5-fluoro-indan-1-ylamino)-quinolin-6-yl]-acetamide

HRID 1928850Notes

Reaction equation

HRID 1928850 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH:11][C:12]1[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH2:22])[CH:18]=3)[N:13]=1)[CH2:6][CH2:5]2.[CH:23]1([CH2:26][C:27](O)=[O:28])[CH2:25][CH2:24]1>>[CH:23]1([CH2:26][C:27]([NH:22][C:17]2[CH:18]=[C:19]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([NH:11][CH:7]2[C:8]4[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=4)[CH2:5][CH2:6]2)[CH:21]=[CH:20]3)=[O:28])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 138440Cyclopropaneacetic acidHCID 68638772HCID 68638772, compound

Product 1

HCID 68916484Rac-2-cyclopropyl-n-[2-(5-fluoro-indan-1-ylamino)-quinolin-6-yl]-acetamide

Procedure

The title compound was prepared in accordance with the general method 14 described in example 119 from rac-N2-(5-fluoro-indan-1-yl)-quinoline-2,6-diamine and cyclopropyl acetic acid; MS: m/e=376.2 (M+H+).

Sources & evidence

ORD record
ord-c7a6b36797434e1ab5d97e365520a3b9
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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