(4-Methylpiperazin-1-yl)acetic acid → HCID 68917729, compound

HRID 1928875Notes

Reaction equation

HRID 1928875 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:11]2[CH:12]([NH:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[C:21]([NH2:26])[CH:22]=4)[N:17]=3)[CH2:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1.[CH3:27][N:28]1[CH2:33][CH2:32][N:31]([CH2:34][C:35](O)=[O:36])[CH2:30][CH2:29]1>>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:11]2[CH:12]([NH:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[C:21]([NH:26][C:35](=[O:36])[CH2:34][N:31]5[CH2:32][CH2:33][N:28]([CH3:27])[CH2:29][CH2:30]5)[CH:22]=4)[N:17]=3)[CH2:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 2762732(4-Methylpiperazin-1-yl)acetic acidHCID 68913498HCID 68913498, compound

Product 1

HCID 68917729HCID 68917729, compound

Procedure

The title compound was prepared from rac-N2-[4-(2-methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine (Example 174) (200 mg, 0.4 mmol) and commercially available (4-methyl-piperazin-1-yl)-acetic acid (68 mg, 0.6 mmol) in accordance with the general method 14 described in example 119 and was obtained as an off-white solid (160 mg, 76%); MS: m/e=492.3 (M+H+).

Sources & evidence

ORD record
ord-157b3c852f5f4b45993a3e6f9432a5ff
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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