HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylene oxide → [1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yl]-carbamic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylene oxide | HCID 11208 | — |
| Reactant | ethyl N-(piperidin-4-yl)carbamate | HCID 15595030 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | [1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yl]-carbamic acid ethyl ester | HCID 68631449 | 97% |
Reaction Steps
A mixture of commercially available ethyl piperidin-4-ylcarbamate (2.067 g, 12 mmol) and isobutylene oxide (868 mg, 12 mmol) in ethanol (15 mL) was irradiated in a microwave apparatus at 110° C. for 90 min. Purification by silica gel column chromatography with ethyl acetate gave the title compound as a colorless oil (2.838 g, 97%); MS: m/e=245.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183380B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-7bc56b8899dd4890b9e22e4953127a5f |
| Source note | uspto-grants-2012_05 |