Cyclopropanecarboxylic acid → HCID 91545665, compound

HRID 1928880Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[C:18]([NH2:23])[CH:19]=4)[N:14]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH:24]1([C:27](O)=[O:28])[CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[C:18]([NH:23][C:27]([CH:24]5[CH2:26][CH2:25]5)=[O:28])[CH:19]=4)[N:14]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 15655Cyclopropanecarboxylic acid

HCID 68631849HCID 68631849, compound

Product 1

HCID 91545665HCID 91545665, compound

Procedure

The title compound was prepared from rac-N2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-quinoline-2,6-diamine (Example 173) (154 mg, 0.5 mmol) and commercially available cyclopropanecarboxylic acid (40 ul, 0.5 mmol) in accordance with the general method 14 described in example 119 and was obtained as an off-white solid (68 mg, 36%); MS: m/e=376.3 (M+H+).

Sources & evidence

ORD record: ord-f1acb5ce96f44d149efff18679df5004
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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