HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1928883Generated: October 30, 2026
Hydroxyamine hydrochloride → 6-Fluoro-benzofuran-3-one oxime
https://huagongshe.com/reaction/1928883
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 6-Fluoro-2,3-dihydro-1-benzofuran-3-one | HCID 18354312 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Fluoro-benzofuran-3-one oxime | HCID 86634187 | 80% |
Reaction Steps
A mixture of 6-fluoro-benzofuran-3-one (CAS 351528-80-8) (5.93 g, 39 mmol), sodium acetate (6.587 g, 80 mmol) and hydroxylamine hydrochloride (5.553 g, 80 mmol) in ethanol (70 ml) was refluxed for 4 h. Cooled to 23° C., filtered the precipitate off, washed with aqueous ethanol and dried in high vacuum to give the title compound as a white solid (5.19 g, 80%, HPLC 1.489 min); MS (ISN) m/e=168.1 [(M−H)−].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183380B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-1164b264e5ac461a8127294feabcb5b8 |
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| Source note | uspto-grants-2012_05 |
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