HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1,2-Epoxypropane → 2,2-Dimethyl-propionic acid 1-((R)-2-hydroxy-propyl)-piperidin-4-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1,2-Epoxypropane | HCID 146261 | — |
| Reactant | Piperidin-4-yl pivalate | HCID 57464983 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,2-Dimethyl-propionic acid 1-((R)-2-hydroxy-propyl)-piperidin-4-yl ester | HCID 67523670 | — |
Reaction Steps
A solution of piperidine 52 (2 g, 10.8 mmol) and (R)-2-Methyl-oxirane (3.78 ml, 54 mmol) in 2 ml of ethanol is stirred for 24 hours in a closed flask. The solvent is evaporated and the residue distilled in a Kugelrohr apparatus (0.08 mbar, 75-90 C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-5231fa53895b4c8bac700933dd71f0a4 |
| Source note | uspto-grants-2012_05 |