Hydrochloric Acid → 1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-piperidin-4-ol trihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	1,4-Dioxane	HCID 31275	—
Reactant	1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride	HCID 66841322	—
Reactant	HCID 66841883	HCID 66841883	—
Product	1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-piperidin-4-ol trihydrochloride	HCID 66841433	—

It is prepared by BOC-cleavage of tert-butyl ester 55 (0.666 g, 1.95 mmol) with 4M−HCl in dioxane (2.93 ml, 11.72 mmol) as described for amine 7.