Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1929032Generated: October 31, 2026

1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-piperidin-4-ol trihydrochloride → 4-Cyclopropylmethoxy-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

https://huagongshe.com/reaction/1929032

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-piperidin-4-ol trihydrochlorideHCID 66841433—
Reactant4-(cyclopropylmethoxy)-1H-indole-2-carboxylic acidHCID 66841434—
Product4-Cyclopropylmethoxy-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amideHCID 11419668—

Reaction Steps

This compound is synthesized analogously to example 1 from 4-cyclopropylmethoxy-1H-indole-2-carboxylic acid, 77 (see example 4) and amine 50.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08183366B2
Source datasetuspto-grants-2012_05
ORD IDord-d3209fc16fc54c2f8e1b838adefcf354
Source noteuspto-grants-2012_05