HuagongsheHuagongshe Chemistry Print Report · For research reference only
Furfuryl Alcohol → 4-(furan-2-ylmethoxy)-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Furfuryl Alcohol | HCID 7361 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | Ethyl 4-hydroxy-1H-indole-2-carboxylate | HCID 13274763 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(furan-2-ylmethoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66841995 | — |
Reaction Steps
DEAD (2.1 ml, 13.65 mmol) is slowly added to a solution of 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester 79 (2 g, 9.75 mmol), triphenylphosphine (3.58 g, 13.65 mmol) and furan-2-yl-methanol (1.18 ml, 12.26 mmol) in 10 ml of THF, so that the temperature always remained below 30° C. Stirring is continued for 2 hours and the solvent is then evaporated. The crude residue is purified by chromatography (cyclohexane:EtOAc/95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1d60d69efccd4239aaf66d48a0fb4f60 |
| Source note | uspto-grants-2012_05 |