HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1929078Generated: November 1, 2026
Di-tert-butyl dicarbonate → 1-tert-butyl 2-ethyl 4-(benzyloxy)-1H-indole-1,2-dicarboxylate
https://huagongshe.com/reaction/1929078
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | Ethyl 4-(phenylmethoxy)-1H-indole-2-carboxylate | HCID 119707 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-tert-butyl 2-ethyl 4-(benzyloxy)-1H-indole-1,2-dicarboxylate | HCID 59152675 | — |
Reaction Steps
4-Benzyloxy-1H-indole-2-carboxylic acid ethyl ester (50 g, 169.3 mmol) is dissolved in 500 ml of ethyl acetate and DMAP (141 mg, 3.4 mmol) is added. Then the mixture is cooled to 0° C. and BOC2O (36.9 g, 169.3 mmol), dissolved in 20 ml of ethyl acetate, is added dropwise. After completion of addition the reaction mixture is allowed to stir over night at room temperature. The mixture is washed with 1M tartaric acid and brine. The organic layers are dried over sodium sulfate and evaporated
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183366B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-6d148e3be6994a82b3c8d9dff3ce0be0 |
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| Source note | uspto-grants-2012_05 |
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