HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1929092Generated: October 30, 2026
Ethyl chloroacetate → Ethyl 2-(3-fluorophenoxy)acetate
https://huagongshe.com/reaction/1929092
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl chloroacetate | HCID 7751 | — |
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Ethyl 2-(3-fluorophenoxy)acetate | HCID 15078057 | — |
Reaction Steps
3-Fluoro-phenol (100 g, 892 mmol) is dissolved in acetone (250 ml) and after addition of chloro-acetic acid ethyl ester (114 ml, 1.07 mol) and K2CO3 (249 g, 1.78 mol) the mixture is refluxed for 24 h. After cooling down to 0° C., the mixture is filtrated and the filtrate is evaporated under reduced pressure. Yield: 198 g (100%) of a red oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183366B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-b3917699bc0c479f86a0dff5bf8afec0 |
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| Source note | uspto-grants-2012_05 |
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