Sulfuric Acid → 6-Fluoro-benzofuran-2,3-dicarboxylic acid diethyl ester

Participants

Reaction Steps

108 (66 g, 221.3 mmol) is dissolved in 245 ml of cooled (−15° C.) conc. sulfuric acid and stirred for 3 h whereas the reaction mixture slowly warmed up to room temperature. Then the mixture is poured onto 1 kg of ice and extracted with diethyl ether. The organic layers are washed with brine, dried over sodium sulfate, filtrated and evaporated. The crude product is used in the next step without further purification.

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