HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1929098Generated: November 1, 2026
Potassium Hydroxide → 4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
https://huagongshe.com/reaction/1929098
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-(6-Fluoro-benzofuran-3-ylmethoxy)-indole-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester | HCID 66841657 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid | HCID 66841531 | — |
Reaction Steps
112 (1.2 g, 2.6 mmol) is dissolved in 30 ml of a 1:1:1 mixture of THF, ethanol and water. And after addition of KOH pellets (742 mg, 13.2 mmol) the mixture is stirred for 2 h (TLC control) at 85° C. Then the organic solvent are removed under reduced pressure. The residue is cooled to 0° C. and treated with 2M HCl. The crude product is filtered off and dried under high vacuum. The crude product (800 mg) is recrystallized from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08183366B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-e4be19c0914a4fe298b14ec3f6a53c63 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
