HCID 66841531, compound → HCID 11168992, compound

HRID 1929102Notes

Reaction equation

HRID 1929102 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]2[C:6]([CH2:9][O:10][C:11]3[CH:19]=[CH:18][CH:17]=[C:16]4[C:12]=3[CH:13]=[C:14]([C:20]([OH:22])=O)[NH:15]4)=[CH:7][O:8][C:4]=2[CH:3]=1.Cl.Cl.Cl.[NH2:28][CH:29]1[CH2:34][CH2:33][N:32]([CH2:35][C@@H:36]([N:38]2[CH2:43][CH2:42][C@H:41]([OH:44])[C@@H:40]([CH3:45])[CH2:39]2)[CH3:37])[CH2:31][CH2:30]1>>[OH:44][C@H:41]1[CH2:42][CH2:43][N:38]([C@@H:36]([CH3:37])[CH2:35][N:32]2[CH2:31][CH2:30][CH:29]([NH:28][C:20]([C:14]3[NH:15][C:16]4[C:12]([CH:13]=3)=[C:11]([O:10][CH2:9][C:6]3[C:5]5[CH:23]=[CH:24][C:2]([F:1])=[CH:3][C:4]=5[O:8][CH:7]=3)[CH:19]=[CH:18][CH:17]=4)=[O:22])[CH2:34][CH2:33]2)[CH2:39][C@@H:40]1[CH3:45]

Participants

3

Reactant 2

HCID 66841531HCID 66841531, compoundHCID 66841745(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

Product 1

HCID 11168992HCID 11168992, compound

Procedure

This compound is synthesized analogously to example 1 from 4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 106 (see example 55) and amine 56.

Sources & evidence

ORD record
ord-1e3e3490a3904876bf05a70cc0d94af5
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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