HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride → 4-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride | HCID 66841496 | — |
| Reactant | 4-(4-Methoxy-benzofuran-3-ylmethoxy)-indole-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester | HCID 66841573 | — |
| Product | 4-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid | HCID 66841369 | — |
Reaction Steps
The title compound is prepared from ester 125 by cleavage with KOH/EtOH/THF (as described in example 50 for 105).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-46e40afd53bd4f3494a086ec0ad24680 |
| Source note | uspto-grants-2012_05 |