4-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(4-Methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

HRID 1929140Notes

Reaction equation

HRID 1929140 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[C:9]([CH2:12][O:13][C:14]3[CH:22]=[CH:21][CH:20]=[C:19]4[C:15]=3[CH:16]=[C:17]([C:23](O)=[O:24])[NH:18]4)=[CH:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl.Cl.Cl.[NH2:29][CH:30]1[CH2:35][CH2:34][N:33]([CH2:36][C@@H:37]([N:39]2[CH2:44][CH2:43][CH:42]([OH:45])[CH2:41][CH2:40]2)[CH3:38])[CH2:32][CH2:31]1>>[OH:45][CH:42]1[CH2:41][CH2:40][N:39]([C@@H:37]([CH3:38])[CH2:36][N:33]2[CH2:32][CH2:31][CH:30]([NH:29][C:23]([C:17]3[NH:18][C:19]4[C:15]([CH:16]=3)=[C:14]([O:13][CH2:12][C:9]3[C:8]5[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=5[O:11][CH:10]=3)[CH:22]=[CH:21][CH:20]=4)=[O:24])[CH2:35][CH2:34]2)[CH2:44][CH2:43]1

Participants

3

Reactant 2

HCID 668413694-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841433HCID 66841433, compound

Product 1

HCID 114557664-(4-Methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 122 (see example 94) and amine 50.

Sources & evidence

ORD record
ord-9a36ac31451645828599c542f72f94c2
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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