4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(4,6-Dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 1929143Notes

Reaction equation

HRID 1929143 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[C:9]([CH2:12][O:13][C:14]3[CH:22]=[CH:21][CH:20]=[C:19]4[C:15]=3[CH:16]=[C:17]([C:23](O)=[O:24])[NH:18]4)=[CH:10][O:11][C:7]=2[CH:6]=[C:5]([O:26][CH3:27])[CH:4]=1.Cl.Cl.Cl.[NH2:31][CH:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][N:40]2[CH2:45][CH2:44][CH:43]([OH:46])[CH2:42][CH2:41]2)[CH2:34][CH2:33]1>>[OH:46][CH:43]1[CH2:42][CH2:41][N:40]([CH2:39][CH2:38][N:35]2[CH2:34][CH2:33][CH:32]([NH:31][C:23]([C:17]3[NH:18][C:19]4[C:15]([CH:16]=3)=[C:14]([O:13][CH2:12][C:9]3[C:8]5[C:3]([O:2][CH3:1])=[CH:4][C:5]([O:26][CH3:27])=[CH:6][C:7]=5[O:11][CH:10]=3)[CH:22]=[CH:21][CH:20]=4)=[O:24])[CH2:37][CH2:36]2)[CH2:45][CH2:44]1

Participants

3

Reactant 2

HCID 668412194-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841786HCID 66841786, compound

Product 1

HCID 114218224-(4,6-Dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 126 (see example 99) and amine 21.

Sources & evidence

ORD record
ord-9ae4a835e43d4e0a8b65b7ce9eef4441
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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