4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → HCID 59600180, compound

HRID 1929146Notes

Reaction equation

HRID 1929146 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[C:9]([CH2:12][O:13][C:14]3[CH:22]=[CH:21][CH:20]=[C:19]4[C:15]=3[CH:16]=[C:17]([C:23]([OH:25])=O)[NH:18]4)=[CH:10][O:11][C:7]=2[CH:6]=[C:5]([O:26][CH3:27])[CH:4]=1.Cl.Cl.Cl.[NH2:31][CH:32]1[CH2:37][CH2:36][N:35]([CH2:38][C@@H:39]([N:41]2[CH2:46][CH2:45][C@H:44]([OH:47])[C@@H:43]([CH3:48])[CH2:42]2)[CH3:40])[CH2:34][CH2:33]1>>[OH:47][C@H:44]1[CH2:45][CH2:46][N:41]([C@@H:39]([CH3:40])[CH2:38][N:35]2[CH2:34][CH2:33][CH:32]([NH:31][C:23]([C:17]3[NH:18][C:19]4[C:15]([CH:16]=3)=[C:14]([O:13][CH2:12][C:9]3[C:8]5[C:3]([O:2][CH3:1])=[CH:4][C:5]([O:26][CH3:27])=[CH:6][C:7]=5[O:11][CH:10]=3)[CH:22]=[CH:21][CH:20]=4)=[O:25])[CH2:37][CH2:36]2)[CH2:42][C@@H:43]1[CH3:48]

Participants

3

Reactant 2

HCID 668412194-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841745(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

Product 1

HCID 59600180HCID 59600180, compound

Procedure

This compound is synthesized analogously to example 1 from 4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 126 (see example 99) and amine 56.

Sources & evidence

ORD record
ord-73df38ac26084202ab251ef88dc857df
Source dataset
uspto-grants-2012_05
Patent number
US08183366B2

Reaction notes

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