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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1929162Generated: October 29, 2026

4-p-tolyloxy-1H-indole-2-carboxylic acid → 4-p-Tolyloxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

https://huagongshe.com/reaction/1929162

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-p-tolyloxy-1H-indole-2-carboxylic acidHCID 66841347—
Reactant1-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochlorideHCID 66841393—
Product4-p-Tolyloxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amideHCID 59600261—

Reaction Steps

This compound is synthesized analogously to Example 1 from 4-p-tolyloxy-1H-indole-2-carboxylic acid 137 (preparation see below) and amine 5.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08183366B2
Source datasetuspto-grants-2012_05
ORD IDord-4e0bb18b3f4d4e46bc2e3ce7da8d90bd
Source noteuspto-grants-2012_05