HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3,5-Difluoro-2-nitro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester → 4-(2-Amino-3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3,5-Difluoro-2-nitro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66842102 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(2-Amino-3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66841906 | — |
Reaction Steps
154 (1.8 g, 4.87 mmol) is dissolved in 150 ml of ethyl acetate and, after addition of Pd—C (500 mg), the mixture is hydrogenated at room temperature for 2 hours. The mixture is filtrated over celite to remove the catalyst and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b599bbaea7b9483098e75661e12f616e |
| Source note | uspto-grants-2012_05 |