HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-(3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-(3,5-Difluoro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66841428 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid | HCID 66841640 | — |
Reaction Steps
156 (260 mg, 0.82 mmol) is dissolved in 10 ml of methanol and treated with a solution of LiOH (40 mg, 1.6 mmol) in 5 ml of water. The mixture is stirred at room temperature for 18 hours. After evaporation, the crude product is acidified at 0° C. with 2M HCl and extracted with ethyl acetate. The organic layers are dried over sodium sulphate and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f95e245b6b8c493ba8b6a8b752580b5d |
| Source note | uspto-grants-2012_05 |