HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-tert-butyl 2-ethyl 4-(benzyloxy)-1H-indole-1,2-dicarboxylate → 1-tert-butyl 2-ethyl 4-hydroxy-1H-indole-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-tert-butyl 2-ethyl 4-(benzyloxy)-1H-indole-1,2-dicarboxylate | HCID 59152675 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-tert-butyl 2-ethyl 4-hydroxy-1H-indole-1,2-dicarboxylate | HCID 59600138 | — |
Reaction Steps
158 (8 g, 20 mmol) is dissolved in 80 ml of ethyl acetate and, after addition of 5% Pd—C (700 mg), the mixture is hydrogenated at room temperature for 7 hours. The mixture is filtrated over celite to remove the catalyst and evaporated. The solid is suspended in ether/hexane and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183366B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a114fd81fb6d4b1f84d5b957dedd5af2 |
| Source note | uspto-grants-2012_05 |