HRID1929198

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H]1CN(C[C@@H](C)O)CC[C@H]1OC(=O)C(C)(C)C

HCID66841456

未命名化合物

结构：O=C(NC1CCNCC1)c1cc2c(OCc3ccoc3)cccc2[nH]1

HCID66841576

未命名化合物

结构：C[C@@H](CN1CCC(NC(=O)OC(C)(C)C)CC1)N1CCC(O)CC1

HCID66841883

未命名化合物

PRODUCTS

生成物

结构：C[C@@H]1CN([C@@H](C)CN2CCC(NC(=O)c3cc4c(OCc5ccoc5)cccc4[nH]3)CC2)CC[C@H]1O

HCID59600255

未命名化合物

PROCEDURE

实验过程

This compound is synthesized from 4-(furan-3-ylmethoxy)-1H-indole-2-carboxylic acid piperidin-4-ylamide, 165 (see example 133) and 2,2-dimethyl-propionic acid (3R,4R)-1-((R)-2-hydroxy-propyl)-3-methyl-piperidin-4-yl ester, 164 (preparation see example 130) analogously to the method described in example 127, followed by pivaloyl cleavage as described for amine 55.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de2f3e6ef0b14a14876f3a97f86b9744
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08183366B2
来源说明: uspto-grants-2012_05

反应 SMILES

[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[C:16]([O:19][CH2:20][C:21]2[CH:25]=[CH:24][O:23][CH:22]=2)[CH:15]=[CH:14][CH:13]=3)=[O:9])[CH2:3][CH2:2]1.O[C@H:27](C)[CH2:28][N:29]1[CH2:34][CH2:33][C@@H:32]([O:35]C(=O)C(C)(C)C)[C@H:31]([CH3:42])[CH2:30]1.[C:44](OC(=O)NC1CCN(C[C@@H](N2CCC(O)CC2)C)CC1)(C)(C)C>>[OH:35][C@@H:32]1[CH2:33][CH2:34][N:29]([C@@H:28]([CH3:27])[CH2:44][N:1]2[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]3[NH:11][C:12]4[C:17]([CH:18]=3)=[C:16]([O:19][CH2:20][C:21]3[CH:25]=[CH:24][O:23][CH:22]=3)[CH:15]=[CH:14][CH:13]=4)=[O:9])[CH2:3][CH2:2]2)[CH2:30][C@H:31]1[CH3:42]