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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1929231Generated: October 31, 2026

4-bromo-1H-indole-2-carboxylic acid → 4-Bromo-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amide

https://huagongshe.com/reaction/1929231

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-bromo-1H-indole-2-carboxylic acidHCID 4042604—
Reactant8-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochlorideHCID 66841574—
Product4-Bromo-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amideHCID 66841447—

Reaction Steps

This compound is synthesized from 4-Bromo-1H-indole-2-carboxylic acid and amine 24 analogously to the method described for 194 (see example 156).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08183366B2
Source datasetuspto-grants-2012_05
ORD IDord-58e1eb13149b480ea141d08b9f43c00d
Source noteuspto-grants-2012_05