HCID 68419193, compound → HCID 14766008, compound

Participants

Reaction Steps

The compound (11) was dissolved in a mixed solvent of toluene (150 ml) and Solmix A-11 (150 ml), and 0.86 g of Pd/C(NX type) was added thereto. The mixture was stirred at room temperature under a hydrogen atmosphere until hydrogen absorption had ceased. After the reaction had been completed, Pd/C was removed and then the solvent was distilled off. The residue obtained was purified with a fractional operation by means of column chromatography using heptane as the eluent and silica gel as the stationary phase powder, and further purified by means of recrystallization from Solmix A-11, and dried, giving 44.7 g of 4-heptyl-1-(3-fluorophenyl)-cyclohexane (12). The yield based on the compound (12) was 75.8%.

Provenance & Evidence