Methyl iodide → HCID 67042273, compound

Participants

Reaction Steps

3.18 g (13.0 mmol) of ethyl 3-amino-4-chloro-2-nitrobenzoate were introduced in DMF and admixed under a nitrogen atmosphere with 0.624 g (15.6 mmol) of sodium hydride. The mixture was left with stirring for 30 minutes and then 2.21 g (15.6 mmol) of methyl iodide were added. After a further 2.5 h of stirring at room temperature the mixture was concentrated and the residue was extracted with ethyl acetate, washed with water, and then dried over MgSO4. The product was then subjected to chromatographic separation (silica gel, heptane/ethyl acetate 9:1).

Provenance & Evidence