Water → HCID 67041952, compound

Participants

Reaction Steps

3.01 g (11.6 mmol) of ethyl 4-chloro-3-(methylamino)-2-nitrobenzoate were dissolved in 35 ml of tetrahydrofuran and 22 ml of water and this solution was admixed with 0.5 g (20.9 mmol) of lithium hydroxide. It was left with stirring for 8 h and then concentrated. The residue was taken up in water and washed with methylene chloride, and the aqueous phase was then adjusted to a pH of 1 using a KHSO4 solution. The precipitate was isolated by filtration with suction, washed with water, and dried under reduced pressure at 70° C.

Provenance & Evidence