Sodium Bicarbonate → HCID 67041941, compound

Participants

Reaction Steps

3.76 g (10.47 mmol) of methyl 4-bromo-3-[(2,2-dimethylpropanoyl)amino]-2-nitro-benzoate were suspended in toluene and admixed with 6 ml (11.26 mmol) of borane-dimethyl sulfide (2M in toluene). The mixture was left with stirring under reflux for 15 h and then cooled. Thereafter, 50 ml of saturated NaHCO3 solution were added, stirring was carried out again at RT for 30 min, and then the organic phase was separated off, dried over MgSO4 and concentrated. The product was then subjected to chromatographic separation (silica gel, heptane/ethyl acetate 4:1).

Provenance & Evidence