Water → HCID 67042000, compound

Participants

Reaction Steps

0.88 g (2.55 mmol) of methyl 4-bromo-3-[(2,2-dimethylpropyl)amino]-2-nitrobenzoate was dissolved in 10 ml of tetrahydrofuran and 10 ml of water and admixed with 0.064 g (2.67 mmol) of lithium hydroxide. The mixture was left with stirring for 15 h and then concentrated. The residue was taken up in water and washed with methylene chloride and the aqueous phase was adjusted to a pH of 1 using a KHSO4 solution. The precipitate was isolated by filtration with suction, washed with water and dried under reduced pressure at 70° C.

Provenance & Evidence