1,3-Cyclohexanedione → HCID 67041881, compound

Participants

Reaction Steps

190 mg (0.574 mmol) of 4-bromo-3-[(2,2-dimethylpropyl)amino]-2-nitrobenzoic acid, 198 mg (1.713 mmol) of cyclohexane-1,3-dione, 145 mg (0.741 mmol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and 7 mg (0.057 mmol) of 4-(dimethylamino)pyridine were dissolved in 5 ml of methylene dichloride and stirred at RT for 24 h. The solution was then washed with water and saturated NaHCO3 solution, the organic phase was dried over MgSO4, and then the whole was filtered with suction through a glass frit, filled with 1 cm of silica gel, and the filter product was washed with heptane/ethyl acetate 1:2. The filtrate was concentrated.

Provenance & Evidence