2-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid → HCID 69676915, compound

HRID 1929297Notes

Reaction equation

[C:1]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)[C:2]1C=CC=CC=1.[N:26]1(CC(O)=O)[CH:34]=[C:32]([CH3:33])[C:30](=[O:31])[NH:29][C:27]1=[O:28]>>[NH:26]1[CH:34]=[C:32]([CH3:33])[C:30](=[O:31])[NH:29][C:27]1=[O:28].[C:1]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(=[O:28])[CH3:2]

Participants

Reactant 2

HCID 8537532-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid

HCID 114729311-Tritylpiperazine

Product 1

HCID 69676915HCID 69676915, compound

Procedure

According to the general procedure, the title compound was prepared using PS-trityl-piperazine resin (Novabiochem) and thymine-1-acetic acid (Aldrich): HPLC/MS M+H=253 fnd., (0.29 min, 100%).

Workup

custom(0.29 min, 100%)

Sources & evidence

ORD record: ord-04a0e84fb5e24cc294a3e1c4a97f75b0
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188011B1

Reaction notes

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