HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 17954765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 7-Methoxy-4-nitro-1-(phenylsulfonyl)indole | HCID 15286320 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 17954765 | HCID 17954765 | — |
Reaction Steps
To a solution of 1-benzenesulfonyl-7-methoxy-4-nitro-1H-indole (R) (1 eq) in methanol was added a solution of sodium hydroxide (5 eq) in water. The solution was heated to reflux for 3 hrs. Methanol was removed under reduced pressure then water and ethyl acetate were added. The ethyl acetate layer separated and washed repeatedly (3×) with water. The ethyl acetate layer was concentrated and evaporated to dryness to produce the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188075B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c1fcef5ad04b4070a23a8191630947c4 |
| Source note | uspto-grants-2012_05 |