2-Amino-6-benzothiazolol → [1-(2,6-Dichloropyridin-4-yl)ethoxy]-1,3-benzothiazol-2-amine

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Reaction Steps

6-[1-(2,6-Dichloropyridin-4-yl)ethoxy]-1,3-benzothiazol-2-amine can be prepared as in Example 8 but from 0.50 g of 2-amino-1,3-benzothiazol-6-ol and 0.723 g of 4-(bromomethyl)-2,6-dichloropyridine. After purification of the residue by silica-column flash chromatography [eluent: dichloromethane/methanol (95/5 by volume)], we obtain 306 mg of -[1-(2,6-dichloropyridin-4-yl)ethoxy]-1,3-benzothiazol-2-amine in the form of a beige solid, which has the following characteristics:

Provenance & Evidence