Trifluoroacetic acid → HCID 178519870, compound

Participants

Reaction Steps

Trifluoroacetic acid (5 ml) was added to (2-fluoropyridin-3-yl)(1-trityl-1H-imidazol-4-yl)methanone (1.1 g, 2.54 mmol). The reaction mixture was stirred for 18 hours. The crude mixture was concentrated in vacuo and treated with a 2N aqueous solution of HCl. The aqueous phase was extracted with diethyl ether and basified with NaOH pellets. The compound was extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound (250 mg, 51% yield).

Provenance & Evidence