HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate | HCID 12717439 | — |
Reaction Steps
Ethyl 4-fluorobenzoate (11.65 g, 69.3 mmol), 1,4-dioxa-8-azaspiro[4.5]decane (9.92 g, 69.3 mmol), and triethylamine (9.66 mL, 69.3 mmol) in N,N-dimethylacetamide (80 mL) were stirred at 80° C. for 24 hours. The reaction was cooled, poured into ethyl acetate, washed with 3× water and brine, and concentrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188077B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-5ec619838252497eaa6255c64b7ebc87 |
| Source note | uspto-grants-2012_05 |