HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylparaben → 4-(2-Adamantan-1-yl-ethoxy)-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol | HCID 110810 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Adamantan-1-yl-ethoxy)-benzoic acid ethyl ester | HCID 57474989 | — |
Reaction Steps
Ethyl 4-hydroxybenzoate (83 mg) and 1-adamantaneethanol (90 mg) were combined in tetrahydrofuran (2 mL). Polymer-supported triphenylphosphine (250 mg of 3 mmol/g) and di-tert-butyl azodicarboxylate (173 mg) were added. The reaction was stirred at room temperature overnight. The resin was removed by filtration through celite. The filtrate was concentrated under vacuum, and the residue was triturated with 95/5 hexanes/ether to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188077B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-7bf738318fe74cfb8ab5524277e69bf3 |
| Source note | uspto-grants-2012_05 |