4-Fluorophenylboronic acid → HCID 66789768, compound

HRID 1929433Notes

Reaction equation

HRID 1929433 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6]([CH3:14])([CH3:13])[C:5]2=[O:15].[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:20]1[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=1)[C:7](=[O:12])[C:6]([CH3:13])([CH3:14])[C:5]2=[O:15]

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 66789948HCID 66789948, compound

Product 1

HCID 66789768HCID 66789768, compoundYield 75.5%

Procedure

6-bromo-3,3-dimethylquinolin-2,4-(1H,3H)-dione (1.0 g) and 4-fluorophenyl-boronic acid (1.04 g) were treated in the same manner as described in Reference Example 1(2) to obtain 6-bromo-1-(4-fluorophenyl)-3,3-dimethylquinolin-2,4-(1H,3H)-dione (1.02 g) as a colorless solid.

Sources & evidence

ORD record
ord-132a3ac62bec4d47bf7409514ae78ff5
Source dataset
uspto-grants-2012_05
Patent number
US08188073B2

Reaction notes

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