2-Bromo-1,3-benzothiazole → HCID 67340550, compound

HRID 1929454Notes

Reaction equation

HRID 1929454 reaction equation
[NH2:1][C:2]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[C:5]2[N:6](C3C=CC(F)=CC=3)[C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[O:9][C:4]=2[CH:3]=1.Br[C:27]1[S:28][C:29]2[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=2[N:31]=1>>[NH2:1][C:2]1[CH:21]=[C:20]([C:22]([F:23])([F:24])[F:25])[C:5]2[N:6]([C:27]3[S:28][C:29]4[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=4[N:31]=3)[C:7](=[O:12])[C:8]([CH3:10])([CH3:11])[O:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 6120402-Bromo-1,3-benzothiazoleHCID 66790334HCID 66790334, compound

Product 1

HCID 67340550HCID 67340550, compoundYield 5.4%

Procedure

7-Amino-4-(4-fluorophenyl)-2,2-dimethyl-5-(trifluoromethyl)-2H-1,4-benzoxazin-3(4H)-one (compound obtained in Reference Example 3(1), 200 mg) and 2-bromobenzothiazole (445 mg) were treated in the same manner as described in Reference Example 61 to give 7-amino-4-(1,3-benzothiazol-2-yl)-2,2-dimethyl-5-(trifluoromethyl)-2H-1,4-benzoxazin-3(4H)-one (12 mg) as a pale yellow powder.

Sources & evidence

ORD record
ord-91969a13467e4675a88bf6bd9bd423ae
Source dataset
uspto-grants-2012_05
Patent number
US08188073B2

Reaction notes

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