HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-bromo-2-fluoro-N-methoxy-N-methylbenzamide → (5-Bromo-2-fluorophenyl)(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide | HCID 60629520 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (5-Bromo-2-fluorophenyl)(cyclopropyl)methanone | HCID 53405397 | — |
Reaction Steps
In an analogous manner to that described for the preparation of Building block C [a)], the reaction of 5-bromo-2-fluoro-N-methoxy-N-methyl-benzamide with cyclopropylmagnesium bromide in tetrahydrofuran yielded the title compound as a light yellow liquid; (HPLC 2.783 min 100%). Mass (calculated) C10H8BrFO [243.074]; (found) [M+H]+=243, [M+2-H]+=245.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188079B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b8d362aeb98c4869875bf1f61a674324 |
| Source note | uspto-grants-2012_05 |