HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66931489, compound → (RS)-[5-(3-Amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66931489 | HCID 66931489 | — |
| Reactant | (RS)-{5-[3-(benzhydrylidene-amino)-phenyl]-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine | HCID 86651222 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (RS)-[5-(3-Amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine | HCID 66931557 | — |
Reaction Steps
Following the general procedure described below the palladium-catalyzed amination of (RS)-[bis-(4-methoxy-phenyl)-phenyl-methyl]-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-amine followed by the hydrolysis of the intermediate (RS)-{5-[3-(benzhydrylidene-amino)-phenyl]-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine yielded the title compound. Mass (calculated) C32H33N3O3 [507.64]; (found) [M+H]+=508.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188079B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-007d8191046a44369f4c46a38b07a5d7 |
| Source note | uspto-grants-2012_05 |