Ammonium Chloride → (R)-5-(5-Bromo-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Participants

Reaction Steps

In analogy to step a) in the synthesis of Building block I, the treatment of (R)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-morpholin-3-one followed by the nucleophilic substitution with ammonium chloride yielded the title compound; its hydrochloride was obtained as a white solid (74% of theory). Mass (calculated) C11H12BrFN2O [287.13]; (found) [M+H]+=287, [M+2-H]+=289.

Provenance & Evidence