Hydrochloric Acid → HCID 58155290, compound

Participants

Reaction Steps

A solution of (S)-2-methyl-propane-2-sulfinic acid [(R)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1,2-dimethyl-propyl]-amide (4.2 g, 11.04 mmol) in tetrahydrofuran (200 ml) was cooled to 0° C. Hydrochloric acid (4 M in dioxane, 11 ml) was added dropwise. The ice bath was removed and stirring continued for 1.5 hours at room temperature. For the workup, the reaction mixture was poured onto a sodium carbonate solution (2 M), extracted twice with ethyl acetate, dried over sodium sulfate, and evaporated at reduced pressure, finally dried under high vacuum. The (R)-3-amino-3-(5-bromo-2-fluoro-phenyl)-2-methyl-butan-2-ol was obtained as light yellow oil (2.94 g, 96.4% of theory). Mass (calculated) C11H15BrFNO [276.147]; (found) [M+H]+=276, [M+2-H]+=278.

Provenance & Evidence