Ammonia → (RS)-5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-(5-amino-3-cyclopropyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Participants

Reaction Steps

In an analogous manner to that described in example 6 (Method B), the condensation of 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (CAS 881409-53-6) and (RS)-5-(5-amino-2-fluoro-phenyl)-5-cyclopropyl-morpholine-3-thione followed by the treatment with tert-butyl hydroperoxide and ammonia yielded the title compound (23) as a white solid. Mass (calculated) C21H20F4N4O3 [452.406]; (found) [M+H]+=453.

Provenance & Evidence